ANDROGEN RECEPTOR AGONIST

ANDROGEN RECEPTOR AGONIST

The present invention provides nonsteroidal tetrahydroquinoline derivatives of general formula (I) or salts thereof: (R , R , X, Y, Z and m are as defined in claim 1) which show no excessive action on the prostate but show a particularly potent androgen receptor agonistic action on skeletal muscle t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MOTONORI MIYAKAWA, HIROAKI NEJISHIMA, KIYONOSHIN ICHIKAWA, KEIGO HANADA, SEIJI AMANO, YUJI SUMITA, KAZUYUKI FURUYA, NORIKO YAMAMOTO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides nonsteroidal tetrahydroquinoline derivatives of general formula (I) or salts thereof: (R , R , X, Y, Z and m are as defined in claim 1) which show no excessive action on the prostate but show a particularly potent androgen receptor agonistic action on skeletal muscle tissue and bone tissue, as well as pharmaceuticals comprising such derivatives or their salts as active ingredients.