ANTI-RETROVIRAL 5,6-DISUBSTITUTED ACYCLOPYRIMIDINE NUCLEOSIDE DERIVATIVES

ANTI-RETROVIRAL 5,6-DISUBSTITUTED ACYCLOPYRIMIDINE NUCLEOSIDE DERIVATIVES

The present invention provides novel pyrimidine nucleoside derivatives represented by the following formula (I): HN I R2 CH (CH2)n 2,X 1 SIMILAR D3 wherein R represents e.g. an alkyl group; RZ represents e.g. a phenyl group or a 3,5-dimethylphenyl group; and R represents e.g. a vinyl group or a ethy...

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Bibliographische Detailangaben
Hauptverfasser: ANNE MARIE BOEL, BENT FABER VESTERGAARD, NASSER R. EL-BROLLOSY, BERIT DAHAN, ERIK BJERREGAARD PEDERSEN, CLAUS NIELSEN, PER TROLLE JORGENSEN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention provides novel pyrimidine nucleoside derivatives represented by the following formula (I): HN I R2 CH (CH2)n 2,X 1 SIMILAR D3 wherein R represents e.g. an alkyl group; RZ represents e.g. a phenyl group or a 3,5-dimethylphenyl group; and R represents e.g. a vinyl group or a ethynyl group; A, B and X represent e.g. oxygene atoms; Z represents e.g. a methylene group or a carbonyl group; n is e.g. 1. The compounds were found to be highly active against wild-type and mutant HIV-1.