Method for producing 2-(-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)-chromane

The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing condition...

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Bibliographische Detailangaben
Hauptverfasser: UDO HELM, ELKE SIMON, HEINZ-HERMANN BOKEL, RALF DEVANT, RALF KNIERIEME, HELMUT REUBOLD, LUDWIG GANTZERT, STEFFEN NEUNFELD
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.