ENHANCER SEQUENCE OF THE 5-AMINOLEVULINIC SYNTHASE GENE

Nucleic acid sequences mediating chemical compound induced 5-aminolevulinate synthase gene (ALAS1) expression are disclosed. Said sequences comprise at least a DR-4 binding site. Furthermore, in vitro methods for testing chemical compounds for modulation of heme and/or P 450 cytochromes synthesis ar...

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Bibliographische Detailangaben
Hauptverfasser: URS, ALBERT MEYER, MICHEL, R. KAUFMANN, DAVID, JOHN FRASER, ADRIAN ZUMSTEG, MICHAEL PODVINEC
Format: Patent
Sprache:eng
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Zusammenfassung:Nucleic acid sequences mediating chemical compound induced 5-aminolevulinate synthase gene (ALAS1) expression are disclosed. Said sequences comprise at least a DR-4 binding site. Furthermore, in vitro methods for testing chemical compounds for modulation of heme and/or P 450 cytochromes synthesis are described.