Transgenic animals comprising a humanized immune system

The invention relates to transgenic non-human animals capable of producing heterologous T-cell receptors and transgenic non-human animals having inactivated endogenous T-cell receptor genes. The invention also relates to methods and vectors and transgenes for making such transgenic non-human animals...

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Bibliographische Detailangaben
Hauptverfasser:	HING, C. WONG, VAUGHAN, P. WITTMAN, JON, A. WEIDANZ, HEATHER, J. BELMONT
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to transgenic non-human animals capable of producing heterologous T-cell receptors and transgenic non-human animals having inactivated endogenous T-cell receptor genes. The invention also relates to methods and vectors and transgenes for making such transgenic non-human animals.