RECOMBINANT B OLIGOMER OF PERTUSSIS TOXIN

RECOMBINANT B OLIGOMER OF PERTUSSIS TOXIN

A genetically-engineered B oligomer-like multimeric protein of pertussis toxin, useful as a non-reactogenic component in an anti-pertussis vaccine, is produced by expressing the individual cistronic elements for subunits S2, S3, S4, and S5 separately in a heterologous host, recovering the resultant...

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Bibliographische Detailangaben
Hauptverfasser: W. NEAL BURNETTE, VERNON L MAR
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A genetically-engineered B oligomer-like multimeric protein of pertussis toxin, useful as a non-reactogenic component in an anti-pertussis vaccine, is produced by expressing the individual cistronic elements for subunits S2, S3, S4, and S5 separately in a heterologous host, recovering the resultant subunit polypeptides, and assembling them by association in vitro to form a multimeric composite.