Method and device for predicting haplotypes

The invention relates to a method for processing gene sequences of diploid organisms. According to said method, for each observed genotype g from a predetermined proband group, the quantity of the possible haplotype pairs (x, y) and the probability of their occurrence is predicted and the following...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: WILLI SCHMIDT
Format: Patent
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to a method for processing gene sequences of diploid organisms. According to said method, for each observed genotype g from a predetermined proband group, the quantity of the possible haplotype pairs (x, y) and the probability of their occurrence is predicted and the following steps are carried out: determination of the haplotypes x from the totality of haplotypes that are compatible with the genotype g; determination of pairs (x, y) of g-compatible haplotypes, of which the genotype g can be composed; determination of the probabilities h(g, x) of the haplotype pairs by a statistical estimation procedure and the output, storage and/or display of at least one haplotype pair, which has a predetermined minimum probability.