Apparatus and method for multiple channel high throughput purification

A multiple channel purification system (10) for purifying a plurality of samples from a chemical library. The system (10) uses chromatography, and preferably, super critical fluid chromatography. Four parallel channels are coupled to a common analyzer (16), such as a mass spectometer and a computer...

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Bibliographische Detailangaben
Hauptverfasser:	JONATHAN D. KRAKOVER, DON WENDELL, WILLIAM C RIPKA, ROMAINE MAIEFSKI
Format:	Patent
Sprache:	eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS SEPARATION TESTING TRANSPORTING
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Beschreibung
Zusammenfassung:	A multiple channel purification system (10) for purifying a plurality of samples from a chemical library. The system (10) uses chromatography, and preferably, super critical fluid chromatography. Four parallel channels are coupled to a common analyzer (16), such as a mass spectometer and a computer (18). Samples in each channel pass through an SFC column (32) to separate the sample, a UV detector (34) to detect sample peaks within the sample flow, a micro sample valve (38) to split a portion of the sample to the common analyzer (16), and a fraction collection valve (43). While the remainder of the sample continues to the fraction collection valve (43), the mass spectrometer (16) analyzes the split portion to determine if a target compound is within the sample portion. The fraction collection valve (43) directs the sample portions to one of two fraction collectors (22, 24) depending on target compound pressence.