PREALBUMIN PURIFICATION & COMPOSITIONS

1511602 Compositions containing human serum prealbumin SYNTEX (USA) INC 18 March 1976 [24 March 1975 18 July 1975 17 Feb 1976] 11009/76 Heading A5B [Also in Division C3] An injectable pharmaceutical solution useful for increasing immunological competence comprises a therapeutically effective amount of human serum prealbumin, essentially free from cytotoxic impurities and from normal human blood serum, dissolved in a pharmaceutically acceptable non-toxic solvent. Such a prealbumin may be prepared by subjecting a Coha IV-1 blood fraction to (a) molecular filtration on a hollow fiber fractionator to exclude material having a M.W. above 60-70,000 daltons and below 10,000 daltons and (b) chromatography on a polysaccharide gel column OR by subjecting the Cohn IV-1 fraction to (a) ammonium sulphate fractionation and (b) chromatography on a polysaccharide gel column.