2,2-DISUBSTITUIERTE BENZOPYRAN-LEUKOTRIEN-D4ANTAGONISTEN

This invention relates to 2,2-di-substituted benzopyran compounds which possess leukotriene-D4 (LTD4) antagonistic activity. In particular this invention relates to LTD4 antagonists of the formula: or a pharmaceutically acceptable addition salt thereof, wherein R is methyl, phenyl, wherein X1 and X2 may be the same or different and are members of the group comprising hydrogen, -Cl, -Br, -CF3, -NH2, -NO2, or straight or branched chain alkyl of 1-3 carbon atoms; wherein m is an integer from 1-9; wherein n is an integer from 1-5; wherein V is @C=O, -CH(OH)-, or -CH2-; wherein W is hydrogen or straight or branched chain alkyl of 1-6 carbon atoms; wherein Y is hydrogen or -COCH3; wherein Z is -CHO, -COOR , -COR , or -CH2OR ; wherein R is hydrogen, a pharmaceutically acceptable cation, straight or branched chain alkyl having 1-6 carbon atoms, or -CH(CH2OR )2 with the proviso that when Z is -COOR , the R substituent in one -COOR moiety may be the same or different from the R substituent in the other COOR moiety; wherein R is and wherein R and R may be the same or different and are members of the group comprising hydrogen or straight or branched chain alkyl having 1-6 carbon atoms; or wherein N, R , and R may together form a cyclic amine of the formula wherein p is 4 or 5; wherein R is hydrogen, or - @-R ; wherein R is hydrogen, benzyl-, or straight or branched chain alkyl having 1-3 carbon atoms; and wherein R is straight or branched chain alkyl of 1-6 carbon atoms.