VERFAHREN ZUR HERSTELLUNG VON 4-0-ALKYLRHODOMYCINEN

A process for preparing 4-O-alkyl-rhodomycins of the formula I in which R is H, C1-C4-alkyl or an acyl protective group, R is OH, COOCH3, O-Si(C1-C4-alkyl)3 or an O-acyl protective group, where acyl is acetyl, mono-, di- or trihalogenoacetyl with fluorine or chorine as halogen, benzoyl or p-nitroben...

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Bibliographische Detailangaben
1. Verfasser:	KOLAR, CENEK
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	A process for preparing 4-O-alkyl-rhodomycins of the formula I in which R is H, C1-C4-alkyl or an acyl protective group, R is OH, COOCH3, O-Si(C1-C4-alkyl)3 or an O-acyl protective group, where acyl is acetyl, mono-, di- or trihalogenoacetyl with fluorine or chorine as halogen, benzoyl or p-nitrobenzoyl, R is C1-C4-alkyl, R is H or R and R together are a tetraisopropyldisiloxane-1,3-diyl protective group, R is H or a glycosyl radical of the formula II in which R is OH, acetyloxy, NHCOCF3, NH2, a mono- or di-C1-C4-alkyl amino group or a 4-morpholinyl group, R is H, OH, an acetyloxy, trifluoroacetyloxy or p-nitrobenzoyloxy group, and the use thereof for preparing 7-O-glucosyl-rhodomycins which, by reason of their cytostatic activity, are suitable for the treatment of cancers, are described.