VERFAHREN ZUR HERSTELLUNG VON HOCHMOLEKULAREM NATRIUMHYALURONAT DURCH GAERUNG VON STREPTOKOKKEN

A composition of sodium hyaluronate is provided having no skin irritation and no pyrogenicity and inflammatory activity. Such a composition can be obtained by a novel mutant microorganism Streptococcus zooepidemicus HA-116 ATCC 39920. Said strain produces large amounts of high molecular weight hyalu...

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Hauptverfasser:	NIMROD, ABRAHAM, GREENMAN, BENJAMIN, KANNER, DOV, LANDSBERG, MOSHE
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE
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Beschreibung
Zusammenfassung:	A composition of sodium hyaluronate is provided having no skin irritation and no pyrogenicity and inflammatory activity. Such a composition can be obtained by a novel mutant microorganism Streptococcus zooepidemicus HA-116 ATCC 39920. Said strain produces large amounts of high molecular weight hyaluronic acid that is excreted into the medium by the organism when the medium includes a sugar component as the carbon source in a substantially constant concentration between 0.2 and 10 g per literat a pH of 6.5 to 7.5 together with a substantially constant magnesium ion concentration that is above 0.05 g per liter.