PERHYDROTHIAZEPIN-DERIVATE, IHRE HERSTELLUNG UND IHRE PHARMAZEUTISCHE ANWENDUNG

PERHYDROTHIAZEPIN-DERIVATE, IHRE HERSTELLUNG UND IHRE PHARMAZEUTISCHE ANWENDUNG

Compounds of formula (I):(wherein: R1 represents an optionally substituted alkyl, cycloalkyl, aryl, partially hydrogenated aryl or heterocyclic group; R2, R3, R4 and R5 represent hydrogen or an optionally substituted alkyl, cycloalkyl, aralkyl, aryl, heterocyclic or heterocyclic-alkyl group or any a...

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Hauptverfasser: ISHIHARA, SADAO SANKYO ICAL RESEAR, TSUJITA, YOSHIO SANKYO FERMENTATION RE, KANAZAKI, TAKURO SANKYO ICAL RESEA, YANAGISAWA, HIROAKI SANKYO ICAL RE, KOIKE, HIROYUKI SANKYO BIOLOGICAL RESE, ANDO, AKIKO SANKYO ICAL RESEARCH L, SHINAGAWA-KU
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of formula (I):(wherein: R1 represents an optionally substituted alkyl, cycloalkyl, aryl, partially hydrogenated aryl or heterocyclic group; R2, R3, R4 and R5 represent hydrogen or an optionally substituted alkyl, cycloalkyl, aralkyl, aryl, heterocyclic or heterocyclic-alkyl group or any adjacent pair thereof form a cyclic structure, at least one not being hydrogen; A represents a bond, or a methylene, ethylene, oxymethyl or thiomethyl group; B represents an alkylene, alkylidene, cycloalkylene or cycloalkylidene group; and n is 0, 1 or 2) and salts and esters thereof are hypotensive agents.