HERSTELLUNG VON VIERZÄHNIGEN PEPTIDCHELATKONJUGATEN ZUR DIAGNOSE VON KOLOREKTALEM KREBS

A peptide-chelate conjugate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaceutical composition comprising the metal complex is provided. wh...

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Bibliographische Detailangaben
Hauptverfasser:	DIXON, MARK, STOREY, ANTHONY, BACON, EDWARD, WOLFE, HENRY, DESAI, VINAY, CUTHBERTSON, ALAN, KASINA, SUDAKAR, MENDIZABAL, MARIVI
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	A peptide-chelate conjugate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaceutical composition comprising the metal complex is provided. which is suitable for the diagnostic imaging of colorectal cancer. Also provided for in the invention is a kit for the preparation of the radiopharmaceutical preparation.