REKOMBINANTES ALPHA-FETOPROTEIN, VERFAHREN UND MITTEL ZUR HERSTELLUNG DAVON, ZUSAMMENSETZUNGEN AUF BASIS DAVON UND VERWENDUNG DAVON

REKOMBINANTES ALPHA-FETOPROTEIN, VERFAHREN UND MITTEL ZUR HERSTELLUNG DAVON, ZUSAMMENSETZUNGEN AUF BASIS DAVON UND VERWENDUNG DAVON

The invention relates to the microbiological and medical industry, genetic engineering, biotechnology. A Saccharomyces cerevisiae yeast strain was obtained on the basis of constructing a recombinant plasmid DNA comprising a structural gene of a human alpha-fetoprotein (AFP) under the control of a re...

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Hauptverfasser: BENEVOLENSKY, SERGEI VLADIMIROVICH, SHINGAROVA, LYUDMILA NIKOLAEVNA, DUDICH, IGOR V, SEMENKOVA, LIDIYA N, DUDICH, ELENA I, DUDICH, DMITRY I, MARCHENKO, ALEXEI NIKOLAEVICH, ZATSEPIN, SERGEI SERGEEVICH, TATULOV, EDUARD BORISOVICH, KOZLOV, DMITRY GEORGIEVICH
Format: Patent
Sprache:ger
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Zusammenfassung:The invention relates to the microbiological and medical industry, genetic engineering, biotechnology. A Saccharomyces cerevisiae yeast strain was obtained on the basis of constructing a recombinant plasmid DNA comprising a structural gene of a human alpha-fetoprotein (AFP) under the control of a regulatory promoter, providing the synthesis and production of AFP in a secreted soluble form, this AFP having activity identical or similar to the activity of a human AFP. The obtained recombinant AFP may be used as an active substance for the preparation of therapeutic agents for use in oncology, immunotherapy, cosmetology and also for the diagnosis of cancer and embryonic pathologies.