VERFAHREN, PLASMIDVEKTOREN UND PRIMER ZUR BEURTEILUNG DER HIV-VIRUSFITNESS

VERFAHREN, PLASMIDVEKTOREN UND PRIMER ZUR BEURTEILUNG DER HIV-VIRUSFITNESS

The present invention relates to methods and means for the evaluation of HIV replicative capacity in a given environment. In particular, the invention provides a growth competition assay that can determine relative viral fitness using a recombinant tagged HIV-1 virus system. The methods rely on plas...

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Bibliographische Detailangaben
Hauptverfasser: KRAUS, GUENTER, TODD, ALISON VELYIAN, DE BETHUNE, MARIE-PIERRE T.M.M.G, MAES, BART ANNA JULIEN, DE BAERE, INKY PAUL MADELEINE, MOKANY, ELISA, RIMSKY, LAURENCE TATIANA
Format: Patent
Sprache:ger
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Beschreibung
Zusammenfassung:The present invention relates to methods and means for the evaluation of HIV replicative capacity in a given environment. In particular, the invention provides a growth competition assay that can determine relative viral fitness using a recombinant tagged HIV-1 virus system. The methods rely on plasmid vectors, amplicons, primers and probes, and the generation of replication-competent viruses therefrom. Said methods and materials may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.