MENSCHLICHE UBIQUTIN LIGASE E3. VERWENDUNG FÜR DIE MODULATION VON NF-KAPPA B

Compositions and methods for modulating the activation of nuclear factor B (NF- B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I Bα and/or I B . Such compositions may be used for treating diseases associated with NF- B activation. Modulat...

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Hauptverfasser:	BEN-NERIAH, YINON, LAVON, IRIS, YARON, AVRAHAM, MERCURIO, FRANK, MANNING, ANTHONY M, HATZUBAI, ADA, AMIT, SHARON, DAVIS, MATTI
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	Compositions and methods for modulating the activation of nuclear factor B (NF- B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I Bα and/or I B . Such compositions may be used for treating diseases associated with NF- B activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.