6-(PYRIDINYL)-4-PYRIMIDONDERIVATE ALS INHIBITOREN DER TAU-PROTEINKINASE-1

A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R 1 represents a C 1 -C 12 alkyl; R 2 represents a hydrogen atom or the like; R 3 represents a halogen or the like; q represents an integer of 1 to 7; R 4 represents a...

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Hauptverfasser: FUKUNAGA, KENJI, KOHARA, TOSHIYUKI, HIKI, SHINSUKE, WATANABE, KAZUTOSHI, YOKOSHIMA, SATOSHI, UEHARA, FUMIAKI
Format: Patent
Sprache:ger
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Zusammenfassung:A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R 1 represents a C 1 -C 12 alkyl; R 2 represents a hydrogen atom or the like; R 3 represents a halogen or the like; q represents an integer of 1 to 7; R 4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R 5 represents a C 6 -C 10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).