SULFONE, DIE DIE AKTIVITÄT VON GAMMA-SECRETASE MODULIEREN
Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of gamma-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
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| creator | CHURCHER, IAN HARRISON, TIMOTHY TEALL, MARTIN RICHARD KERRAD, SONIA NADIN, ALAN JOHN OAKLEY, PAUL JOSEPH OWENS, ANDREW PATE DINNELL, KEVIN SHAW, DUNCAN EDWARD WILLIAMS, BRIAN JOHN WILLIAMS, SUSANNAH CASTRO PINEIRO, JOSE LUIS |
| description | Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of gamma-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease. |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SULFONE, DIE DIE AKTIVITÄT VON GAMMA-SECRETASE MODULIEREN |
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