SULFONE, DIE DIE AKTIVITÄT VON GAMMA-SECRETASE MODULIEREN

Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of gamma-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.

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Bibliographische Detailangaben
Hauptverfasser:	CHURCHER, IAN, HARRISON, TIMOTHY, TEALL, MARTIN RICHARD, KERRAD, SONIA, NADIN, ALAN JOHN, OAKLEY, PAUL JOSEPH, OWENS, ANDREW PATE, DINNELL, KEVIN, SHAW, DUNCAN EDWARD, WILLIAMS, BRIAN JOHN, WILLIAMS, SUSANNAH, CASTRO PINEIRO, JOSE LUIS
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of gamma-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.