GAMMA-GLUTAMYL- UND BETA-ASPARTYL-RESTE ENTHALTENDE IMMUNOMODULATOREN UND ENTSPRECHENDE METHODEN

GAMMA-GLUTAMYL- UND BETA-ASPARTYL-RESTE ENTHALTENDE IMMUNOMODULATOREN UND ENTSPRECHENDE METHODEN

FIELD: peptide synthesis. SUBSTANCE: invention provides new peptide with general formula I: (I) wherein R is hydrogen, lower alkyl, or lower acyl; X heteroaromatic amino acid residue; and n=1 or 2; on condition that, when residue RNHCH(COOH)(CH2)nCO- is glutamic acid residue (n= 2), then X has stere...

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Bibliographische Detailangaben
Hauptverfasser: KOLOBOV, ALEXANDER A, WEI, EDWARD, SIMBIRTSEV, ANDREY S
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:FIELD: peptide synthesis. SUBSTANCE: invention provides new peptide with general formula I: (I) wherein R is hydrogen, lower alkyl, or lower acyl; X heteroaromatic amino acid residue; and n=1 or 2; on condition that, when residue RNHCH(COOH)(CH2)nCO- is glutamic acid residue (n= 2), then X has stereo configuration different from that at alpha-carbon atom of glutamic acid having immuno-simulating activity. Preparation having such activity and containing peptide I (0.001 to 0.01 %) and special additives (the balance) is also provided. EFFECT: enlarged choice of immuno-simulating peptides. 2 cl, 11 tbl, 15 ex