ORALES PRÄPARAT MIT KONTROLLIERTER FREISETZUNG

Pharmaceutical pellet comprise a spherical active agent containing core with smooth surface and a coat on the core, where the active agent release is pH-independent and the active agent is metoprolol salt, preferably metoprolol succinate. Independent claims are included for: (1) a collection of pellets, where at least 90% of pellets are as defined in the pharmaceutical pellet; (2) a collective coat, where at least 90% of it fulfill the above defined core; (3) the preparation of the pellet comprising providing an active agent containing pellet core with length-width-ratio of less than 1.4 and an average roughness of less 10 mu m and/or relative average roughness of less than 2%; and spraying an aqueous solution or dispersion containing a film former; (4) a procedure for the production of a tablet comprising mixing the pellet with one or more component such as filler material, binder, decaying agent, flow regulating agent or lubricant to form a mixture, and pressing the mixture to form a tablet; and (5) a tablet, produced according to the above procedure.