PROTEASOMINHIBITOREN UND VERFAHREN ZU DEREN ANWENDUNG

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorde...

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Hauptverfasser: OLIVA, AMBROGIO, CASSARA, PAOLO, IQBAL, MOHAMED, BERNAREGGI, ALBERTO, D'ARASMO, GERMANO, FERRETTI, EDMONDO, DE NUNARI, SERGIO, CHATTERJEE, SANKAR, BERNARDINI, RAFAELLA, MENTA, ERNESTO, MESSINA MCLAUGHLIN, PATRICIA
Format: Patent
Sprache:ger
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Zusammenfassung:The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.