RADIOAKTIVE ARSENVERBINDUNGEN UND IHRE VERWENDUNG ZUR BEHANDLUNG VON TUMOREN

This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, TE-WEI, KAO, CHARNG-FENG, WU, MING-SHIUAN, CHYI, SHYH-YI, CHANG, CHIH-HSIEN, HSU, WEIUAN, FAN, KUO-HSIEN, CHEN, TE-JUNG, HSU, YIN-MAO, CHANG, SHIANG-RONG, HUANG, CHUN-YING, CHANG, KWO-PING, FU, YING-KAI
Format:	Patent
Sprache:	ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i). This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumors.