BEZDIOXAN-PIPERAZIN-DERIVATE MIT EINER KOMBINATION AUS AFFINITAT FUR DOPAMIN-D2- REZEPTOREN UND SEROTONIN-WIEDERAUFNAHME-STELLEN

BEZDIOXAN-PIPERAZIN-DERIVATE MIT EINER KOMBINATION AUS AFFINITAT FUR DOPAMIN-D2- REZEPTOREN UND SEROTONIN-WIEDERAUFNAHME-STELLEN

The present invention relates to a group of novel 3 -(2-piperidin-4-yl-ethyl)-1H-indole derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D2 receptors and to methods for the preparation of these compounds. The invention also relates to the use of a compo...

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Bibliographische Detailangaben
Hauptverfasser: TULP, MARTINUS T.M, VAN HES, ROELOF, SMID, PIETER, KRUSE, CORNELIS G
Format: Patent
Sprache:ger
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Beschreibung
Zusammenfassung:The present invention relates to a group of novel 3 -(2-piperidin-4-yl-ethyl)-1H-indole derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D2 receptors and to methods for the preparation of these compounds. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.