SEMI-SYNTHETISCHES VERFAHREN ZUR HERSTELLUNG VON INSULIN

Human insulin is semi-synthetically prepared using a novel method comprising the preparation of a modified human insulin of the general formula wherein R = H or an enzymatically separable sugar residue or an ester thereof, and R = an enzymatically separable sugar residue or an ester thereof, or an a...

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Bibliographische Detailangaben
Hauptverfasser:	VAN DEDEM, GIJSBERT WILLEM KAREL, VAN HOUDENHOVEN, FRANCOIS EGBERT ABRAH
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Human insulin is semi-synthetically prepared using a novel method comprising the preparation of a modified human insulin of the general formula wherein R = H or an enzymatically separable sugar residue or an ester thereof, and R = an enzymatically separable sugar residue or an ester thereof, or an amino acid or peptide, or an amide or ester of the latter two, or R - OH if R NOTEQUAL H, followed by enzymatic removal of the modifying groups R and/or R to yield human insulin.