GABUSECTIN-DERIVATE, VERFAHREN ZUR DEREN HERSTELLUNG UND DEREN VERWENDUNG

3-(Octahydronaphth-1-yl-methylene)-pyrrolidine derivatives (I) and its derivatives, are new. Gabusectin compounds of formula (I) and their stereoisomers and tautomers (including mixtures in all ratios) and salts are new. R1-R3 = H; or 1-6C alkyl, 2-6C alkenyl or 2-6C alkynyl (all optionally substituted by 1-2 of OH, =O, halo or NH2; or 1-6C alkoxy, 2-6C alkenyloxy, aryl, 1-6C alkylamino or 2-6C alkenylamino (all optionally substituted by CN, amide or oxime functions)); R4 = 1-6C alkyl or 2-6C alkenyl (both optionally substituted as in R1-R3); R5 = H or Me; X1-X5 = O, NH, N-(1-6C alkyl), N-(2-6C alkenyl), N-(2-6C alkynyl), N-acyl, N-aryl, N-O-R1 or S. Independent claims are also included for: (1) the preparation of (I); and (2) the new microorganism ST003236 (DSM 14476).