VERFAHREN ZUR HERSTELLUNG VON 4-Ä(DI)ALKYLAMINOÜ- PYRIDIN-VERBINDUNGEN

VERFAHREN ZUR HERSTELLUNG VON 4-Ä(DI)ALKYLAMINOÜ- PYRIDIN-VERBINDUNGEN

Processes for preparing a 4-(secondary or tertiary)aminopyridine are provided. The processes comprise reacting a 4-substituted pyridine base having a leaving group as the 4-substituent, with an activating agent so as to form a corresponding 1,4-substituted pyridine; reacting the 1,4-substituted pyri...

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Bibliographische Detailangaben
Hauptverfasser: BALASUBRAMANIAN, MARUDAI, SCRIVEN, ERIC, MURUGAN, RAMIAH, HUCKSTEP, MARC, CALVIN, JOEL, HOPPER, CHARLES R
Format: Patent
Sprache:ger
Schlagworte:
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Zusammenfassung:Processes for preparing a 4-(secondary or tertiary)aminopyridine are provided. The processes comprise reacting a 4-substituted pyridine base having a leaving group as the 4-substituent, with an activating agent so as to form a corresponding 1,4-substituted pyridine; reacting the 1,4-substituted pyridine with a primary or secondary amine to substitute an amino group at the 4-position, and thereby form a corresponding 1-substituted-4-(secondary or tertiary) aminopyridine, wherein the reacting is conducted in a substitution reaction medium essentially free from strong base; and treating the 1-substituted-4-aminopyridine compound to remove the 1-substituent and thereby form a product medium including the 4-(secondary or tertiary) amino-pyridine.