1,6-NAPHTHYRIDINDERIVATE, DIE ALS KARDIOTONIKA VERWENDBAR SIND UND IHRE HERSTELLUNG

1,6-NAPHTHYRIDINDERIVATE, DIE ALS KARDIOTONIKA VERWENDBAR SIND UND IHRE HERSTELLUNG

4-R min -5-Q-1,6-naphthyridin-2(1H)-ones (1), where R min is hydrogen or methyl and Q is hydroxymethyl, 1-hydroxyethyl alkanoyloxymethyl or 1-alkanoyloxyethyl, are produced by first reacting 4-R min -5-acetyl (or n-propanoyl)-6[2-(dilower-alkylamino]-2(1H)-pyridinone (III) with hydroxylamine or salt...

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Bibliographische Detailangaben
Hauptverfasser: LESHER, GEORGE YOHE, SINGH, BALDEV
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:4-R min -5-Q-1,6-naphthyridin-2(1H)-ones (1), where R min is hydrogen or methyl and Q is hydroxymethyl, 1-hydroxyethyl alkanoyloxymethyl or 1-alkanoyloxyethyl, are produced by first reacting 4-R min -5-acetyl (or n-propanoyl)-6[2-(dilower-alkylamino]-2(1H)-pyridinone (III) with hydroxylamine or salt thereof to produce 4-R min -5-Q min -1,6-naphthyridin-2(1H)-one-6-oxide (II), where R min is defined as above and Q min is methyl or ethyl; next reacting II with an alkanoic anhydride to produce I where Q is alkanoyloxymethyl or 1-alkanoyloxyethyl; and, then hydrolyzing said alkanoyloxymethyl or -ethyl compound to produce I where Q is hydroxymethyl or 1-hydroxyethyl. Also shown is the cardiotonic use of II and I where Q is hydroxymethyl, 1-hydroxyethyl or alkanoyloxymethyl.