ANTITUMOR WIRKSAME 2-ALKOXYESTRADIOLSULFAMATE

The invention relates to the use of 2-alkoxyestrogen sulfamates of general formula (I) for producing a medicament for the treatment of tumorous diseases, which are positively influenced by the inhibition of tubulin polymerisation. In said formula, R and R independently of one another represent H, methyl, C1-C4 acyl or benzyl, R represents C1-C4 alkyl, or a group of formula CnFmHo, where n = 1, 2, 3, 4, 5 or 6, m > 1 and m + o = 2n + 1, R and R independently represent H, or together represent a methylene group or an additional bond, R represents H and R represents OH, OC1-C4 alkyl, OC1-C11 acyl or OSO2NR R , whereby in the B and C ring of the steroid skeleton the broken lines can additionally represent up to two double bonds. The inventive compounds are characterised by a 2-alkoxy substitution in conjunction with a 17-hydroxy substitution. They exhibit the specific activity of inhibiting tubulin polymerisation and can be used, for example, for treating prostatic carcinoma.