ZYKLISCHE SOMATOSTATIN-ANALOGE MIT EINER HAUPTKETTE MIT EINER GESPANNTEN KONFORMATION

Novel peptide analogs are disclosed. The novel peptides are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comp...

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Bibliographische Detailangaben
Hauptverfasser: SERI-LEVY, ALON, HORNIK, VERED, GILON, CHAIM, GELLERMAN, GARY
Format: Patent
Sprache:ger
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Zusammenfassung:Novel peptide analogs are disclosed. The novel peptides are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions in the treatment of endocrine disorders, neoplasms and metabolic disorders are also disclosed.