VERBESSERTES VERFAHREN FÜR DIE HERSTELLUNG VON WASSERLÖSLICHEN O-PHOSPHONOOXYMETHYL-PRODRUGS

VERBESSERTES VERFAHREN FÜR DIE HERSTELLUNG VON WASSERLÖSLICHEN O-PHOSPHONOOXYMETHYL-PRODRUGS

An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antifungal compounds are provided having the gener...

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Bibliographische Detailangaben
Hauptverfasser: PENDRI, YADAGIRI, MATISKELLA, JOHN, D, CONNOLLY, TIMOTHY PAUL, CHEN, CHUNG-PIN, MUELLER, RICHARD, H, KOLLA, LAXMA, REDDY, PETSCH, DEJAH, T
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antifungal compounds are provided having the general formulawherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and R and R1 are as defined in the specification.