VERFAHREN ZUR HERSTELLUNG AROMATISCHER 2-HYDROXY-3-ISOPROPYL- ODER 2-HYDROXY-3-TERT-BUTYLAMINOPROPYL-AETHER

VERFAHREN ZUR HERSTELLUNG AROMATISCHER 2-HYDROXY-3-ISOPROPYL- ODER 2-HYDROXY-3-TERT-BUTYLAMINOPROPYL-AETHER

Methods and intermediates for introducing the two blocking side chains, 2-hydroxy- 3-isopropyl or tert.-butylaminopropyl, into aromatic nuclei containing a phenolic hydroxyl group by condensing a 5-halomethyl-3-isopropyl or 3-tert. -butyl-2-oxazolidinone with an aromatic compound containing a phenol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KIRKPATRICK, DAVID SAMUEL, WEBB, ROBERT LEE
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Methods and intermediates for introducing the two blocking side chains, 2-hydroxy- 3-isopropyl or tert.-butylaminopropyl, into aromatic nuclei containing a phenolic hydroxyl group by condensing a 5-halomethyl-3-isopropyl or 3-tert. -butyl-2-oxazolidinone with an aromatic compound containing a phenolic hydroxy group in the presence of an acid binding agent at 80-150 DEG C then subsquently splitting the oxazolidinone ring using an alkali metal hydroxide or lower alkoxide at a temperature in the range of 100-150 DEG C in an organic solvent.