BILDUNG UND ANIONENAUSTAUSCH VON INNEREN KRISTALLINEN AMMONIUMSALZEN DES ECHINOCANDINS B

BILDUNG UND ANIONENAUSTAUSCH VON INNEREN KRISTALLINEN AMMONIUMSALZEN DES ECHINOCANDINS B

A method is described for forming a crystalline Echinocandin nucleus salt from its mixed broth and/or partially purified process streams by the steps of nanofiltration to form a concentrate, addition of an aldehyde derivatizing agent which interacts with an aldehyde impurity, addition of an acid/met...

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Hauptverfasser: VAN DEN BERGHE SNOREK, SHARON, LARSEN, SAMUEL, DEAN, DOTLICH, MICHAEL, ANTHONY, VICENZI, JEFFREY, THOMAS, DALDER, BRIAN, WESTON, KALLMAN, NEIL, JOHN
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A method is described for forming a crystalline Echinocandin nucleus salt from its mixed broth and/or partially purified process streams by the steps of nanofiltration to form a concentrate, addition of an aldehyde derivatizing agent which interacts with an aldehyde impurity, addition of an acid/metal salt to form a solubilized echinocandin nucleus salt having the desired anion, and subsequent cooling of the mixture to crystallize the salt.