(BENZODIOXAN, BENZOFURAN, ODER BENZOPYRAN) DERIVATE MIT FUNDIC ENTSPANNUNGSEIGENSCHAFTEN

The present invention of compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk is C1-6alkanediyl optionally substituted with hydroxy, C1-4alkyloxy or C1-4alkylcarbonyloxy; -Z -Z - is a bivalent radical; R , R and R are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; or when R and R are on adjacent carbon atoms, R and R taken together may form a bivalent radical; R is hydrogen or C1-6alkyl; A is a bivalent radical of formula -NR -Alk -(b-1), or -Npiperidinyl-(CH2)m (b-2) wherein m is 0 or 1; R is a radical of formulawherein n is 1 or 2; p is 0, and p is 1 or 2; or p is 1 or 2, and p is 0; X is oxygen, sulfur or =NR ; Y is oxygen or sulfur; R is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impaired fundic relaxation.