CO-LYOPHILISIERTER KOMPLEX UMFASSEND EINEN NUKLEINSÄUREVEKTOR UND EIN FORMULIERUNGSAGENS

The present invention, as noted above, relates generally to the incorporation of plasmid into a conventional dosage form, and more particularly to the production of a single-vial, homogenized, plasmid/polymer complex with desirable physical characteristics. Methods of making, storing and using such...

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Bibliographische Detailangaben
Hauptverfasser: MUMPER, RUSS, LOGAN, MARK, J, TAGLIAFERRI, JENNA, LAWSON, LUKE, BRUNO, MARIA
Format: Patent
Sprache:ger
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Zusammenfassung:The present invention, as noted above, relates generally to the incorporation of plasmid into a conventional dosage form, and more particularly to the production of a single-vial, homogenized, plasmid/polymer complex with desirable physical characteristics. Methods of making, storing and using such a complex are also provided and described in detail below. Such products and methods will provide more convenient and cost-effective complexes, which will be protected against chemical degradation and/or physical aggregation of its components and will provide for relative ease of administration. Thus, the present invention provides a more efficient complex for plasmid delivery and a method of incorporation of that plasmid into a conventional dosage form.