VERFAHREN ZUR HERSTELLUNG CHIRALER, NICHT RACEMISCHER (4-ARYL-2,5-DIOXOIMIDAZOLIDIN-1-YL)- ESSIGSÄUREN

VERFAHREN ZUR HERSTELLUNG CHIRALER, NICHT RACEMISCHER (4-ARYL-2,5-DIOXOIMIDAZOLIDIN-1-YL)- ESSIGSÄUREN

Preparation of chiral, non-racemic compounds of formula (I) comprises carrying out a racemate cleavage of the racemic compound (I) by forming its salt with a chiral, non-racemic amino compound. R1 = H, F, Cl, Br, I, CN, NO2 or OH; R2 = H, F, 1-7C alkyl, phenyl(1-7C)alkyl or 3-8C cycloalkyl. A proces...

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Bibliographische Detailangaben
Hauptverfasser: KULITZSCHER, BERNDT, DL, HOLLA, WOLFGANG, BECK, GERHARD, KAMMERMEIER, BERNHARD, MICHALOWSKY, JUERGEN
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Preparation of chiral, non-racemic compounds of formula (I) comprises carrying out a racemate cleavage of the racemic compound (I) by forming its salt with a chiral, non-racemic amino compound. R1 = H, F, Cl, Br, I, CN, NO2 or OH; R2 = H, F, 1-7C alkyl, phenyl(1-7C)alkyl or 3-8C cycloalkyl. A process for the preparation of the precursor racemate (I) is also claimed.