CHINAZOLIN-4-ON AMPA ANTAGONISTEN

The present invention relates to novel quinazolin-4-one derivatives of the formula I, wherein A is a benzo or thieno fused aromatic ring; B is phenyl, pyridyl or pyrimidyl; X is N or CH; Y and Z, taken together, i.e., Y-Z, are either -CH2NH- or -NHCH2-; R is selected from hydrogen, (C1-C6)alkyl optionally substituted with from one to three fluorine atoms, cyano, halo, amino, nitro and (C1-C6)alkoxy optionally substituted with from one to three fluorine atoms; R is halo, cyano, (C1-C6)alkyl optionally substituted with from one to three fluorine atoms, nitro, amino, (C1-C6)alkylthio, (C1-C6)alkoxy optionally substituted with from one to three fluorine atoms, hydroxy, H-C(=O)-, (C1-C6)alkyl-O-C(=O)- or NH2-C(=O)-; R and R are selected, independently, from hydrogen, (C1-C6)alkyl optionally substituted with from one to three fluorine atoms, halo, cyano, hydroxy (C1-C6)alkoxy optionally substituted with from one to three fluorine atoms, -C(=O)H, -CH2OR and -CH2NR R ; pharmaceutical compositions containing such compounds the use of such compounds to treat neurodegenerative, psychotropic, and drug and alcohol induced central and peripheral nervous system disorders.