METHODE ZUR LÖSUNG, REINIGUNG UND RÜCKFALTUNG VON PROTEIN

Aqueous formulations of TFPI (tissue factor pathway inhibitor) include L-arginine and/or a solubilising agent selected from the group consisting of: an acetate ion; a sulfate ion; sodium chloride; a citrate ion; an isocitrate ion; glycine; glutamate; a succinate ion; histidine; imidazole; sodium dod...

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Bibliographische Detailangaben
Hauptverfasser:	HALENBECK, ROBERT, F, TSANG, MICHAEL, HORA, MANINDER, S, DORIN, GLENN, J, MADANI, HASSAN, PATTISON, GREGORY, L, JOHNSON, GARY, V, JOHNSON, KIRK, RANA, RAJSHARAN, K, GUSTAFSON, MARK, E, BILD, GARY, S, ARVE, BO, H, CHEN, BAO-LU
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	Aqueous formulations of TFPI (tissue factor pathway inhibitor) include L-arginine and/or a solubilising agent selected from the group consisting of: an acetate ion; a sulfate ion; sodium chloride; a citrate ion; an isocitrate ion; glycine; glutamate; a succinate ion; histidine; imidazole; sodium dodecyl sulfate; or a charged polymer. The invention facilitates the solubilization, formulation, purification and refolding of TFPI.