NEUE 2'-O-ALKYL-NUKLEOSIDE UND -PHOSPHORAMIDITE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNGEN

Novel 2'-O-alkyl guanosine compounds and analogs thereof are provided. Processes for the preparation of 2'-O-alkyl guanosine and analogs thereof are also provided. Processes for preparing 2'-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3'-O-phosphoramidites are...

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Hauptverfasser: MCGEE, DANIEL PETER CLAUDE, COOK, PHILLIP DAN, GUINOSSO, CHARLES JOHN
Format: Patent
Sprache:ger
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Zusammenfassung:Novel 2'-O-alkyl guanosine compounds and analogs thereof are provided. Processes for the preparation of 2'-O-alkyl guanosine and analogs thereof are also provided. Processes for preparing 2'-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3'-O-phosphoramidites are also provided. Methods for the use of oligonucleotides comprising 2'-O-alkyl guanosine are also provided.