STABILE INFUSIONSLÖSUNG VON DICLOFENAC-SALZEN, DEREN HERSTELLUNG UND VERWENDUNG

STABILE INFUSIONSLÖSUNG VON DICLOFENAC-SALZEN, DEREN HERSTELLUNG UND VERWENDUNG

Storage-stable aqueous infusion solution (A) of diclofenac (2-(2,6-dichloroanilino)phenylacetic acid) salt (I), in optimal therapeutic concentration, comprises an intravenously tolerable (I) at concentration equivalent to 0.2-0.6 g/l diclofenac sodium; 0.1-1 g/l N-acetyl-L-cysteine (II) as stabilize...

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Bibliographische Detailangaben
Hauptverfasser: HASZONITS, OSKAR, EGGENREICH, UDO, POMPER, HERBERT, FEICHTINGER, NORBERT, WURM, ANNELIESE
Format: Patent
Sprache:ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Storage-stable aqueous infusion solution (A) of diclofenac (2-(2,6-dichloroanilino)phenylacetic acid) salt (I), in optimal therapeutic concentration, comprises an intravenously tolerable (I) at concentration equivalent to 0.2-0.6 g/l diclofenac sodium; 0.1-1 g/l N-acetyl-L-cysteine (II) as stabilizer; 50-100 mg/l disodium ethylenediamine tetraacetic acid dihydrate (III), and substances to provide a physiological osmolarity. (A) has pH 7.6-9.0. An Independent claim is also included for a method of preparing (A).