VERFAHREN ZUR ISOLIERUNG VON 1-(N2-((S- ETHOXYCARBONYL)-3-PHENYLPROPYL)-N6- TRIFLUORACETYL)-L-LYSYL-L-PROLIN (LISINOPRIL(TFA)ETHYLESTER, LPE)

VERFAHREN ZUR ISOLIERUNG VON 1-(N2-((S- ETHOXYCARBONYL)-3-PHENYLPROPYL)-N6- TRIFLUORACETYL)-L-LYSYL-L-PROLIN (LISINOPRIL(TFA)ETHYLESTER, LPE)

Isolation of 1-ÄN -((S)-ethoxycarbonyl)-3-phenylpropyl)-N -trifluoroacetylÜ-L- lysyl-L-proline (I) (i.e. lisinoprilÄTFAÜ ethyl ester) from an aqueous solution obtained in the production of (I), comprises extraction followed by crystallisation. The novelty is that the solvent (or solvent mixture) use...

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Bibliographische Detailangaben
Hauptverfasser: STINGL, KLAUS, KRAFT, MICHAEL, DRAUZ, KARLHEINZ, DR, KOTTENHAHN, MATTHIAS, MOELLER, ROLAND
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Isolation of 1-ÄN -((S)-ethoxycarbonyl)-3-phenylpropyl)-N -trifluoroacetylÜ-L- lysyl-L-proline (I) (i.e. lisinoprilÄTFAÜ ethyl ester) from an aqueous solution obtained in the production of (I), comprises extraction followed by crystallisation. The novelty is that the solvent (or solvent mixture) used for extraction of (I) is also a major component of the solvent (mixture) used for crystallisation of (I). Also claimed is (I) which exhibits reflections at 6.7241, 9.4851, 11.9034, 16.3074 and 17.8722 (2 ).