METHODEN UND ZUSAMMENSETZUNGEN ZUR EMPFINDLICHEN UND SCHNELLEN FUNKTIONELLEN IDENTIFIZIERUNG GENOMISCHER POLYNUKLEOTIDE UND IHRE ANWENDUNG IN ZELLTESTS ZUM AUFFINDEN VON MEDIKAMENTEN

The invention provides methods for determining a cellular response profile for a target or chemical, for screening compounds for activity as an activator or inhibitor of a target and for developing a cell sensor panel. Furthermore, cell sensor panels are provided. Generally, the methods comprise ins...

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Bibliographische Detailangaben
Hauptverfasser:	MERE, LORA, NEGULESCU, PAUL, A, FOULKES, GORDEN, J, CRAIG, FRANK, WHITNEY, MICHAEL, A
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides methods for determining a cellular response profile for a target or chemical, for screening compounds for activity as an activator or inhibitor of a target and for developing a cell sensor panel. Furthermore, cell sensor panels are provided. Generally, the methods comprise inserting a BL (beta-lactamase) expression construct via a viral vector into an non-yeast eukaryotic genome, contained in at least one living cell, contacting the cell with a predetermined concentration of a modulator, and detecting BL activity in the cell.