SUBSTITUIERTE HETEROCYCLISCHE BENZOCYCLOALKENE UND IHRE VERWENDUNG ALS ANALGETISCH WIRKSAME SUBSTANZEN

Aminomethyl substituted heterocyclic benzocycloalkene derivatives (I) are new. Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alky...

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Hauptverfasser: PUETZ, CLAUDIA DR, STRASSBURGER, WOLFGANG DR, ZIMMER, OSWALD DR, ENGLBERGER, WERNER DR, KOEGEL, BABETTE-YVONNE DR
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STRASSBURGER, WOLFGANG DR
ZIMMER, OSWALD DR
ENGLBERGER, WERNER DR
KOEGEL, BABETTE-YVONNE DR
description Aminomethyl substituted heterocyclic benzocycloalkene derivatives (I) are new. Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alkyl; -CH2-CH=C(R )2; or 3-7C cycloalkyl-methyl; R , R = H; Cl; F; CF3; 1-6C alkyl; OH; 1-6C alkoxy; 3-7C cycloalkyloxy; alpha , beta or beta , gamma -O-(CH2)o-O-; -(CH2)n-aryl; heterocyclyl; -O-(CH2)n-aryl; or alpha , beta - or beta , gamma -benzo optionally mono- or disubstituted by F, Cl, CF3, OH, 1-6C alkyl, 1-6C alkoxy or -CON(R R ); R = H or 1-6C alkyl; R = H; 1-6C alkyl; -(CH2)naryl; or CH2-3-7C cycloalkyl; or R + R = -(CH2)m or -(CH2)2-O-(CH2)2-; X = O; S; SO; or SO2; Y = -(CH2)0; -CH2-C(CH3)2-; or -C(CH3)2-; n = 0-2; m = 5-7; o = 1-2. An Independent claim is included for the preparation of compounds (I).
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Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alkyl; -CH2-CH=C(R )2; or 3-7C cycloalkyl-methyl; R , R = H; Cl; F; CF3; 1-6C alkyl; OH; 1-6C alkoxy; 3-7C cycloalkyloxy; alpha , beta or beta , gamma -O-(CH2)o-O-; -(CH2)n-aryl; heterocyclyl; -O-(CH2)n-aryl; or alpha , beta - or beta , gamma -benzo optionally mono- or disubstituted by F, Cl, CF3, OH, 1-6C alkyl, 1-6C alkoxy or -CON(R R ); R = H or 1-6C alkyl; R = H; 1-6C alkyl; -(CH2)naryl; or CH2-3-7C cycloalkyl; or R + R = -(CH2)m or -(CH2)2-O-(CH2)2-; X = O; S; SO; or SO2; Y = -(CH2)0; -CH2-C(CH3)2-; or -C(CH3)2-; n = 0-2; m = 5-7; o = 1-2. 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Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alkyl; -CH2-CH=C(R )2; or 3-7C cycloalkyl-methyl; R , R = H; Cl; F; CF3; 1-6C alkyl; OH; 1-6C alkoxy; 3-7C cycloalkyloxy; alpha , beta or beta , gamma -O-(CH2)o-O-; -(CH2)n-aryl; heterocyclyl; -O-(CH2)n-aryl; or alpha , beta - or beta , gamma -benzo optionally mono- or disubstituted by F, Cl, CF3, OH, 1-6C alkyl, 1-6C alkoxy or -CON(R R ); R = H or 1-6C alkyl; R = H; 1-6C alkyl; -(CH2)naryl; or CH2-3-7C cycloalkyl; or R + R = -(CH2)m or -(CH2)2-O-(CH2)2-; X = O; S; SO; or SO2; Y = -(CH2)0; -CH2-C(CH3)2-; or -C(CH3)2-; n = 0-2; m = 5-7; o = 1-2. An Independent claim is included for the preparation of compounds (I).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title SUBSTITUIERTE HETEROCYCLISCHE BENZOCYCLOALKENE UND IHRE VERWENDUNG ALS ANALGETISCH WIRKSAME SUBSTANZEN
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