PHARMAZEUTISCH AKTIVE COPOLYMERISATE, VERFAHREN ZUR HERSTELLUNG UND DIE COPOLYMERISATE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN

The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation. The new copolymers comprising the units of the general formula /I/derived from /meth/acrylic acid or an ester thereof /X stands...

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Bibliographische Detailangaben
Hauptverfasser: SZPORNY, LASZLO, KARPATI, EGON, LOW, MIKLOS, GYORGYI, JUDIT, NAGY, MIKLOS, KISFALUDY, LAJOS, HORVATH, ISTVAN, MACHOVICH, RAYMUND, CSOMOR, KATALIN
Format: Patent
Sprache:eng ; ger
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Zusammenfassung:The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation. The new copolymers comprising the units of the general formula /I/derived from /meth/acrylic acid or an ester thereof /X stands for hydrogen or methyl and Y is hydrogen/, units of the formula /III/optionally units of the general formula /II//Z' is hydrogen/, and chain terminating units, formed from the units of the formulae /I/, /III/ and optionally /II/ under the conditions of copolymerization, in a statistical arrangement, and the pharmaceutically acceptable salts thereof, which contain, in addition to the above chain-members, units of the general formulae /IV/ and/or /V//X has the same meaning as defined above, and A is a cation/ satisfactorily replace the organogenic heparin, or give a synergistic combination with that.