PROTEIN:PRENYL TRANSFERASE INHIBITOREN

The invention pertains to novel peptide analogues suitable for inhibiting protein:prenyl transferased. The analogues comply with the following formula: in which: R is hydrogen or a thiol-protecting group; R and R are independently hydrogen or C1-C4 alkyl; R is hydrogen, C1-C4 alkyl, C1-C4 acyl or pe...

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Bibliographische Detailangaben
Hauptverfasser:	OVERKLEEFT, HERMAN STEVEN, VERHELST, STEVEN HENDRIK LEONARD, COHEN, LOUIS HARTOG, VAN BOOM, JOCOBUS HUBERTUS, MEEUWENOORD, NICOLAAS JOHANNES, VAN DER MAREL, GIJSBERT ARIE, OVERHAND, MARK, PIETERMAN, ELSBET JANTINE
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention pertains to novel peptide analogues suitable for inhibiting protein:prenyl transferased. The analogues comply with the following formula: in which: R is hydrogen or a thiol-protecting group; R and R are independently hydrogen or C1-C4 alkyl; R is hydrogen, C1-C4 alkyl, C1-C4 acyl or peptidyl; R is hydrogen or C1-C4 alkyl; R is hydrogen or optionally substituted C1-C6 alkyl; A is a direct bond or an optionally substituted C1-C4 alkylene chain; Y represents an oxo group or two hydrogen atoms; Z is oxygen, sulphur, imino or C1-C8 alkyl-, aryl- or acylimino; m is 0, 1 or 2; n is 0 or 1.el