VERFAHREN ZUR HERSTELLUNG VON 1-ALPHA-HYDROXY VITAMIN D ODER 1-ALPHA HYDROXY PREVITAMIN D DERIVATEN UND PREVITAMIN D ODER TACHYSTEROLADDUKTEN MIT GEEIGNETEN DIENOPHILEN

The invention relates to a method of preparing 1 alpha -hydroxyvitamin D or 1 alpha -hydroxy-previtamin D compounds by hydroxylating the 1 alpha -position of an adduct of a previtamin D compound with a suitable dienophile, in which adduct optionally present hydroxy group or hydroxy groups is or are...

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Bibliographische Detailangaben
Hauptverfasser:	VANMAELE, LUC J, HALKES, SEBASTIANUS J, VANDEWALLE, MAURITS, DE CLERCQ, PIERRE J, OVERBEEK, WILHELMUS R.M
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a method of preparing 1 alpha -hydroxyvitamin D or 1 alpha -hydroxy-previtamin D compounds by hydroxylating the 1 alpha -position of an adduct of a previtamin D compound with a suitable dienophile, in which adduct optionally present hydroxy group or hydroxy groups is or are protected, if desired, and after removal of the protecting group or groups, isolating the 1 alpha -hydroxyvitamin D or 1 alpha -hydroxy-previtamin D compound. The invention also relates to 1 alpha -hydroxy-previtamin D compounds. The invention further relates to an adduct of a previtamin D or tachysterol compound with a dienophile of the general formula in which A' and B' are equal and represent methoxy groups or ethoxy groups, or in which A' and B' together constitute a phenylimino or o-phenylene group.