VERFAHREN ZUR RACEMATSPALTUNG VON TRAMADOL

VERFAHREN ZUR RACEMATSPALTUNG VON TRAMADOL

Separating the racemate of tramadol (I) comprises converting a tramadol salt into the base, separating the (-) enantiomer by precipitation with L-(+)-tartaric acid and isolating the (+)-tramadol enantiomer from the mother liquor from tartaric acid precipitation by releasing the base and subsequently...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WINTER, WERNER, DR, JANSEN, PETER, BUSCHMANN, HELMUT, GRAUDUMS, IVARS
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Separating the racemate of tramadol (I) comprises converting a tramadol salt into the base, separating the (-) enantiomer by precipitation with L-(+)-tartaric acid and isolating the (+)-tramadol enantiomer from the mother liquor from tartaric acid precipitation by releasing the base and subsequently converting into a salt which is different form the tartrate. The separated isomer prepared by the process is claimed per se.