VERFAHREN ZUR HERSTELLUNG UND TRENNUNG VON DIASTEREOMEREN SALZEN VON FOLINSÄURE

VERFAHREN ZUR HERSTELLUNG UND TRENNUNG VON DIASTEREOMEREN SALZEN VON FOLINSÄURE

A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine...

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Hauptverfasser: FELDER, ERNST, DISTASO, CARLO, RIPA, GIORGIO
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Sprache:ger
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APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator FELDER, ERNST
DISTASO, CARLO
RIPA, GIORGIO
description A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine and the subsequent separation of the diastereomeric salts.
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subjects APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title VERFAHREN ZUR HERSTELLUNG UND TRENNUNG VON DIASTEREOMEREN SALZEN VON FOLINSÄURE
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