VERFAHREN ZUR HERSTELLUNG UND TRENNUNG VON DIASTEREOMEREN SALZEN VON FOLINSÄURE

VERFAHREN ZUR HERSTELLUNG UND TRENNUNG VON DIASTEREOMEREN SALZEN VON FOLINSÄURE

A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FELDER, ERNST, DISTASO, CARLO, RIPA, GIORGIO
Format: Patent
Sprache:ger
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine and the subsequent separation of the diastereomeric salts.